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ORIGINAL RESEARCH article
Front. Ophthalmol.
Sec. Pediatric Ophthalmology and Strabismus
Volume 5 - 2025 | doi: 10.3389/fopht.2025.1532931
This article is part of the Research Topic Myopia in Childhood and Adolescence View all 7 articles
Associations between refractive error components and higher-order aberrations in simple myopia and compound myopic astigmatism
Provisionally accepted- 1 Shahid Beheshti University of Medical Sciences, Tehran, Iran
- 2 Shiraz University of Medical Sciences, Shiraz, Fars, Iran
Aim: To investigate associations between refractive error components and higher-order aberrations (HOAs) in adult myopic subjects.Methods: A total of 1370 myopia right eyes, aged 18-40, were included in a cross-sectional study. Subjective cycloplegic refractions and distance aberrometry measured with a Shack-Hartmann device were analyzed. Zernike components of horizontal coma (Z3 1 ), vertical coma (Z3 -1 ), oblique trefoil (Z3 3 ), vertical trefoil (Z3 -3 ), spherical aberration, and total root-meansquare (RMS) wave-front error for 6 mm pupil were analyzed. Person's correlations were calculated between sphero-cylindrical components and HOAs based on vector analysis for the astigmatism axis. Total subjects were divided into two subgroups: simple myopia (SMY, 648 eyes) and compound myopic astigmatism (CMA, 722 eyes). HOAs were compared between the two subgroups.Results: Total RMS wave-front error correlates with spherical equivalent myopia (r = -0.1, P<0.05) and J45 (r = 0.1, P<0.001). J0 correlates positively with vertical coma (Z3 -1 ) (r = 0.1 p <0.001) and negatively with oblique trefoil (Z3 3 ) and vertical trefoil (Z3 -3 ), (r = -0.1, p < 0.001; r = -0.1, P < 0.05). The total RMS wavefront-error was larger in the CMA (|0.37| ± 0.18 µm) compared to the SMY (|0.34| ± 0.16 µm, P <0.001). The mean values of vertical coma (Z3 -1 ), vertical trefoil (Z3 -3 ), and oblique trefoil (Z3 3 ) differed between the two subgroups.Total RMS wave-front error increases with increasing myopia and astigmatism.Increasing myopia power does not show a systematic correlation with HOAs components. A weak systematic correlation is suggested between astigmatism direction and third-order aberrations.
Keywords: Higher-order aberration, Myopia, Astigmatism, Coma, Spherical aberration
Received: 22 Nov 2024; Accepted: 26 Feb 2025.
Copyright: © 2025 Mohaghegh, Bamdad and Kangari. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Sahar Mohaghegh, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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