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CASE REPORT article

Front. Ophthalmol.
Sec. Retina
Volume 4 - 2024 | doi: 10.3389/fopht.2024.1509065

Unexpected Retinal Fluid Compartment Responses with Anti-VEGF Therapy Paradoxical Response to Intravitreal Faricimab in Polypoidal Choroidal Vasculopathy: A Case Series of Four Patients

Provisionally accepted
Noa Gilead Noa Gilead 1,2*Yu Jeat Chong Yu Jeat Chong 1,2Farah Ilyana Ibrahim Farah Ilyana Ibrahim 1,2,3Christopher Sun Christopher Sun 1,2,3Kelvin Yi Chong Teo Kelvin Yi Chong Teo 1,2,3Gemmy Cheung Gemmy Cheung 1,2,3
  • 1 Singapore Eye Research Institute (SERI), Singapore, Singapore
  • 2 Singapore National Eye Center, Singapore, Singapore
  • 3 Duke-NUS Medical School, Singapore, Singapore

The final, formatted version of the article will be published soon.

    This case series describes paradoxical responses to faricimab treatment in opposite direction in different fluid compartments in four patients with polypoidal choroidal vasculopathy (PCV). Despite reductions in subretinal fluid (SRF) and stable visual acuity following treatment, all patients developed subretinal pigment epithelial (RPE) elevation. Over a 10-14 months follow-up, three patients exhibited a gradual decrease in RPE elevation, with one case resolving completely. These findings suggest that fluid compartments in PCV may respond differently to treatment and add to the understanding of PCV by highlighting the complex interplay between different retinal fluid compartments in response to treatment.

    Keywords: Polypoidal choroidal vasculopathy (pcv), Subretinal Fluid (SRF), Pigment Epithelial Detachment (PED), ParadoxicalUnexpected Response, Retinal Fluid Compartments, Case Report Font: Bold, Complex Script Font: Not Bold Font: Bold, Complex Script Font: Not Bold

    Received: 10 Oct 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Gilead, Chong, Ibrahim, Sun, Teo and Cheung. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Noa Gilead, Singapore Eye Research Institute (SERI), Singapore, Singapore

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.