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ORIGINAL RESEARCH article

Front. Ophthalmol.
Sec. Cornea and Refractive Surgery
Volume 4 - 2024 | doi: 10.3389/fopht.2024.1488764

Intraoperative Optical Coherence Tomography Imaging for Assessment of Anterior Chamber Gas Fill

Provisionally accepted
Michael Tseng Michael Tseng Avrey Thau Avrey Thau Carla Berkowitz Carla Berkowitz *Abhijit Ramaprasad Abhijit Ramaprasad *Surendra Basti Surendra Basti *
  • Department of Ophthalmology, Northwestern University, Evanston, United States

The final, formatted version of the article will be published soon.

    During endothelial keratoplasty, anterior chamber gas is titrated to a desired fill, which is difficult to optimize by visualization alone. This study evaluates how an anterior chamber gas fill correlates with intraocular pressure (IOP) and iris-angle configuration as identified by optical coherence tomography (OCT). Eleven cadaveric eyes were studied in three configurations: baseline, air-fill just spanning limbus-to-limbus ("full-fill"), and air-fill maximally filling the anterior chamber ("overfill"). At each configuration, IOP was measured by Tonopen and iris-angle was determined by analyzing OCT images with ImageJ. No differences in IOP or iris-angles were identified between baseline and full-fill configurations (p=0.113 and p=0.152, respectively). When compared to overfill configuration, differences in IOP and iris-angles were identified for baseline (p<0.001 and p=0.001, respectively) and full-fill configuration (p=0.001 and p=0.039, respectively). These findings highlight that en-face visualization of full-fill may not be indicative of IOP elevation. A significant difference in IOP and iris-angle exists between full-fill and overfill configurations. Intraoperative OCT can serve as a useful surrogate to identify the extent of fill.

    Keywords: Keratoplasty, Optical Coherence Tomography, Surgical technique, Intraoperative imaging, Intraocular Pressure

    Received: 30 Aug 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Tseng, Thau, Berkowitz, Ramaprasad and Basti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Carla Berkowitz, Department of Ophthalmology, Northwestern University, Evanston, United States
    Abhijit Ramaprasad, Department of Ophthalmology, Northwestern University, Evanston, United States
    Surendra Basti, Department of Ophthalmology, Northwestern University, Evanston, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.