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CASE REPORT article

Front. Ophthalmol.
Sec. Neuro-Ophthalmology Disorders
Volume 4 - 2024 | doi: 10.3389/fopht.2024.1483937
This article is part of the Research Topic Visual Function Evaluation of Congenital and Acquired Diseases in Humans, using Electrophysiological, Psychophysical and Ophthalmological Methods View all articles

Case report: HLA-B35-associated optic neuritis

Provisionally accepted
Andrew R Carey Andrew R Carey *Florian H Guillot Florian H Guillot
  • Wilmer Eye Institute, School of Medicine, Johns Hopkins Medicine, Baltimore, United States

The final, formatted version of the article will be published soon.

    Purpose: To describe a unique presentation of optic neuritis associated with positive HLA-B35.Observations: A woman presented with unilateral retro-orbital pain, mildly decreased vision and optic disc edema with new onset aphthous ulcers. Color vision was preserved, and no visual field deficits were noted. Diagnostic imaging demonstrated retrobulbar optic nerve enhancement, with genetic testing revealing HLA-B35 positivity. Treatment with high dose oral steroids for three days resolved all symptoms and the patient remained stable for at least two months.Conclusions and importance: In addition to rheumatic conditions and oral lesions, HLA-B35 can be linked to optic neuritis. This relationship highlights the need to further explore genetic risk factors associated with optic neuritis and the potential need for HLA testing in unusual cases of optic neuritis.

    Keywords: human leukocyte antigen, HLA-B35, Optic Neuritis, optic neuropathy, Behçets disease, case report Journal and specialty Frontiers in Ophthalmology -Neuro-Ophthalmology Disorders

    Received: 20 Aug 2024; Accepted: 29 Oct 2024.

    Copyright: © 2024 Carey and Guillot. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Andrew R Carey, Wilmer Eye Institute, School of Medicine, Johns Hopkins Medicine, Baltimore, United States

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