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ORIGINAL RESEARCH article

Front. Ophthalmol.
Sec. Pediatric Ophthalmology and Strabismus
Volume 4 - 2024 | doi: 10.3389/fopht.2024.1447558
This article is part of the Research Topic Myopia in Childhood and Adolescence View all articles

Comparison of different concentrations atropine in controlling children and adolescent myopia: an umbrella review of systematic reviews and meta-analyses

Provisionally accepted
Baizhou Chen Baizhou Chen 1Yao Ni Yao Ni 1Jinghan Chen Jinghan Chen 2Shuwen Xing Shuwen Xing 1Zhaotian Zhang Zhaotian Zhang 1*
  • 1 Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China
  • 2 Xinhua College of Sun Yat-sen University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Purpose: To evaluate the myopia control effect of different concentrations atropine in children and adolescent.Methods: Meta-analyses and systematic reviews available in the Pubmed, Embase, and Cochrane Library databases from the databases' inception to August 2023 were searched to evaluate the efficacy and tolerability of different concentrations' atropine in controlling myopia progression. Overall effects were performed using random-effects model. AMSTAR 2 tool was used to assess the quality of included studies. Prespecified outcomes were weight mean difference (WMD) with 95% credible interval (95% CI) of annual spherical equivalent refraction (SER) changes and annual axial length (AL) changes.Results: 19 systematic reviews/meta-analyses of different atropine concentrations were included in the analysis. 14 studies reported SER changes, and 17 reported AL changes. In terms of the studies' overall methodological quality level (measured using AMSTAR 2), 1 study was rated high, 7 moderate, 7 low, and 4 critically low. The 0.01% atropine was found to have statistically significance (annual SER change WMD 0.27 [95% CI 0.21 -0.34] D/year; annual AL change WMD -0.09 [95% CI -0.1 to -0.07]) mm/year), 0.05% atropine was preferred considering efficacy and tolerability (annual SER change WMD 0.54 [95% CI 0.49 -0.58] D/year; annual AL change WMD -0.21 [95% CI -0.12 to -0.02]) mm/year).Conclusions: Different atropine concentrations alleviated children and adolescent myopia progression. However, higher-quality evidence and further investigation are needed to clarify the dose-response relationship, and practical guidelines must be developed to determine myopia control efficacy.

    Keywords: Myopia, Atropine, concentration, Children, Axial length, spherical equivalent refraction (SER)

    Received: 11 Jun 2024; Accepted: 29 Sep 2024.

    Copyright: © 2024 Chen, Ni, Chen, Xing and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhaotian Zhang, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China

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