AUTHOR=Araujo Warlen Miiller Rocha , Ayo Christiane Maria , Previato Mariana , de Faria Geraldo Magela , Frederico Fábio Batista , Siqueira Rubens Camargo , de Almeida Gildásio Castello , Pereira-Chioccola Vera Lúcia , de Mattos Luiz Carlos , Brandão Cinara Cássia 

TITLE=Role of interleukin 1β and interleukin 10 variants on ocular toxoplasmosis in Brazilian individuals

JOURNAL=Frontiers in Ophthalmology

VOLUME=3

YEAR=2023

URL=https://www.frontiersin.org/journals/ophthalmology/articles/10.3389/fopht.2023.1183167

DOI=10.3389/fopht.2023.1183167

ISSN=2674-0826

ABSTRACT=<sec><title>Introduction</title><p>Ocular toxoplasmosis (OT) is an intraocular inflammation caused by <italic>Toxoplasma gondii</italic> infection that affects the retina and choroid, giving rise to posterior uveitis. Genetic polymorphisms in cytokine genes may exert influence in the expression of these molecules and play a significant role in inflammatory responses and susceptibility to OT. The aim of this study was to evaluate the role of polymorphisms rs16944 (–511 C &gt; T) of the <italic>interleukin (IL) 1β</italic> gene and rs1800896 (–1082 G &gt; A) of the <italic>IL10</italic> gene on OT in Brazilian individuals with a serologic diagnosis of <italic>T. gondii</italic> and after conducting fundoscopic exams.</p></sec><sec><title>Methods</title><p>Participants with a positive serology were classified into two distinct groups according to the presence (G1; <italic>n</italic> = 110) or absence (G2; <italic>n</italic> = 104) of OT. The control group (G3) consisted of individuals without the infection (<italic>n </italic>= 108).</p></sec><sec><title>Results</title><p>It was observed that the C/C genotype of the <italic>IL1β</italic> gene polymorphism was a protective factor for OT (<italic>p</italic> = 0.02, OR = 0.28, 95% CI 0.08–0.78 for G1 vs. G2; <italic>p</italic> = 0.03; OR = 0.29, 95% CI 0.09–0.82 for G1 vs. G3), according to the recessive inheritance model.</p></sec><sec><title>Conclusions</title><p>The -511C.T polymorphisms of the <italic>IL1β</italic> gene seems to play an important role in the pathogenesis of OT in Brazilian individuals.</p></sec>