AUTHOR=Sheldon Claire A. , Reggie Sara N. , Paley Grace L. , McCormack Shana E. , Liu Grant T. 

TITLE=Effects of acetazolamide on linear growth in children with pseudotumor cerebri syndrome

JOURNAL=Frontiers in Ophthalmology

VOLUME=2

YEAR=2023

URL=https://www.frontiersin.org/journals/ophthalmology/articles/10.3389/fopht.2022.1042529

DOI=10.3389/fopht.2022.1042529

ISSN=2674-0826

ABSTRACT=<sec><title>Background/introduction</title><p>While oral acetazolamide is a cornerstone of management of adult and pediatric PTCS, previous studies have suggested that acetazolamide used in children with other conditions may influence growth.</p></sec><sec><title>Aims and methods</title><p>Retrospective chart review involving a single tertiary medical center. Thirty-four children with definite or probable PTCS were identified. Analysis was restricted to individuals from whom anthropometric data were available <italic>before</italic> and <italic>during</italic> acetazolamide treatment (n=22).</p></sec><sec><title>Results</title><p>Half of individuals (n=11/22) showed a decline in BMI Z-scores. Sixty-three percent (n=14/22) showed a decrease in height Z-scores during treatment with acetazolamide; in 6 of these 14 children who had complete data, 3 showed at least a partial recovery of height Z-scores after discontinuation of acetazolamide.</p></sec><sec><title>Conclusion</title><p>Acetazolamide may be associated with growth suppression in some children treated for pediatric PTCS. In some cases, the growth suppression appears to reverse once the acetazolamide is stopped.</p></sec>