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CASE REPORT article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1597194
Phosphaturic Mesenchymal Tumor Presenting Solely as Knee Pain without Hypophosphatemia: A Case Report
Provisionally accepted- People's Hospital of Zhengzhou University, Zhengzhou, China
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Phosphaturic mesenchymal tumor (PMT) is a rare tumor disease that often leads to tumor-induced osteomalacia (TIO). The typical manifestations of this disease include hypophosphatemia and osteomalacia. The main symptom in most PMT patients is diffuse pain throughout the body. However, we report a PMT patient with typical histological features but without hypophosphatemia and TIO. This patient only presented with pain in the right knee joint. At 6 months and 1 year after surgery, follow -up revealed that the patient's swelling and pain in the right knee joint had disappeared.Moreover, the imaging and biochemical examinations conducted at the local hospital showed normal results.
Keywords: Phosphaturic mesenchymal tumors, Tumor-induced osteomalacia, Fibroblast growth factor 23, Pain, Hypophosphatemia, Osteomalacia
Received: 25 Mar 2025; Accepted: 16 Apr 2025.
Copyright: © 2025 Cao, Cheng and Dai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhipeng Dai, People's Hospital of Zhengzhou University, Zhengzhou, China
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