ORIGINAL RESEARCH article
Front. Oncol.
Sec. Radiation Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1589270
This article is part of the Research TopicInnovative Approaches in Precision Radiation OncologyView all 9 articles
Effect of physical parameter differences on the performance of a knowledgebased partial arc VMAT RapidPlan model for left breast cancer
Provisionally accepted
- 1First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
- 2Jiangxi Cancer Hospital, Nanchang, Jiangxi Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objective To optimize the protection of organs at risk (OARs) in left breast cancer radiotherapy, this study investigated how physical parameter adjustments affect the performance of a Rapidplanbased dose-volume histogram (DVH) prediction model. Methods Twenty patients who underwent left breast-conserving surgery were enrolled. Partial arc volumetric modulated arc therapy (VMAT) plans were designed per patient, with X-direction field width set to half-beam and right breast (Breast-R ) contoured as an avoidance structure to generate Rapidplan model. The model was used to predict and generate three plans: AP_partial arc (avoidance structure prioritized), RP_partial arc (no avoidance structure), and FP_partial arc (expanded field width). Dosimetric comparisons against the original plan evaluated the impact of parameter selection. Results AP_partial arc reduced mean doses of Breast-R, Heart, Lung-L, and Lung-R by 7.7 cGy, 9.8 cGy, 16.7 cGy, and 1.1 cGy, respectively (p < 0.05). Conversely, RP_partial arc increased mean dose of Breast-R by 66.3 cGy (p < 0.05). FP_partial arc raised V5 of Lung-L , V5 of Heart, and mean dose of Lung-L by 4.01%, 2.25%, and 36 cGy (p < 0.05).The knowledge-based partial arc model for rapid planning of left breast cancer accurately predicts the DVH of OARs. However, before performing dose prediction, physical parameters such as radiation field width and planned avoidance structures should be considered to reduce the risk of low-dose exposure volume to OARs and secondary cancer.
Keywords: Left breast cancer, DVH, RapidPlan, partial arc VMAT, Dosimetry
Received: 07 Mar 2025; Accepted: 22 Apr 2025.
Copyright: © 2025 Guo, Lu, Zhong and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huaiwen Zhang, Jiangxi Cancer Hospital, Nanchang, Jiangxi Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.