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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1587648
This article is part of the Research TopicPathophysiology and Therapeutic Strategies for Oral and Head and Neck CancersView all 10 articles
Comparative Efficacy of Surgery and Radiotherapy in Achieving Local Control in Kimura Disease: A Retrospective Analysis of Treatment Outcomes
Provisionally accepted- First Affiliated Hospital of Fujian Medical University, Fuzhou, China
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Objective: To evaluate and compare the impact of surgery versus radiotherapy on local control rates in Kimura disease (KD). Methods: A retrospective analysis was conducted on 26 patients diagnosed with KD at the First Affiliated Hospital of Fujian Medical University from January 2001 to January 2024. Patients were categorized into four treatment groups: Primary Surgery (PS), Primary Radiotherapy (PR), Salvage Surgery (SS), and Salvage Radiotherapy (SR) following recurrence.Data on demographics, tumor characteristics, eosinophil counts (EO), disease duration, and radiation dose were collected. Univariate and multivariate analyses were performed to identify factors influencing local control rates. Results: The cohort had a mean age of 42.2 ± 17.7 years, with 24 male patients. Kaplan-Meier analysis revealed that radiotherapy provided superior local control compared to surgery, with significant differences between PS and PR (p = 0.047) and SS and SR (p < 0.001). No significant difference was found between PR and SR (p = 0.816). Multivariate analysis identified treatment modality as the strongest predictor of recurrence (HR: 0.062). Additionally, factors such as radiotherapy, bilateral involvement, and longer disease duration were associated with improved local control. Among radiotherapy patients, age, tumor number, tumor size, pre-treatment eosinophil count, radiotherapy dose, and disease duration significantly influenced prognosis. Conclusion: Radiotherapy is more effective than surgery in achieving local control of Kimura disease. Higher radiation doses may negatively impact outcomes, suggesting that a tailored, moderate-dose approach is optimal. Radiotherapy should be prioritized, particularly for recurrent or multifocal cases, offering a more reliable long-term treatment strategy than surgery.
Keywords: Kimura Disease1, surgery2, radiotherapy3, Local Control4, recurrence5
Received: 04 Mar 2025; Accepted: 10 Apr 2025.
Copyright: © 2025 Lv, Chen, Wang, Li, Liu and Hong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jinsheng Hong, First Affiliated Hospital of Fujian Medical University, Fuzhou, China
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