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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Pediatric Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1584631
This article is part of the Research Topic Immunological Therapies in Pediatric Cancers: A Latin American Perspective View all 3 articles
Haploidentical, matched-related, and matched-unrelated hematopoietic cell transplant for acute leukemias in the early years of haploidentical transplant implementation in a developing country with a large unrelated donor registry
Provisionally accepted
Adriana Seber 1
LEONARDO ARCURI 2* Vergilio Rensi Colturato 3
MAIR PEDRO SOUZA 3 Yana Zogbi 4 Decio Lerner 5 Maria Cristina Macedo 6
Liane Daudt, Liane Esteves Daudt, Esteves Daudt, Liane 7
Mariana Nassif Kerbauy 2 Victor Gottardello 8 Fernando Barroso Duarte 9 Ricardo Rabello Chiattone 1 Rodolfo Soares 10 Gustavo Bettarello 11
Antonio Vaz De Macedo 12 Eduardo Paton 13 Tatiana Monteiro 14 Jayr Schmidt Filho 15 Claudia Astigarraga 16
Phillip Scheinberg 8 Afonso Vigorito 17 Carmen Vergueiro 18 Anderson Simione 3 Vaneuza Funke 19 Shahrukh Hashmi 20 Wael Saber 20 Jinalben Patel 20
Carmem Bonfim 21 Marcelo Pasquini 20 Mary Evelyn Flowers 22
Nelson Hamerschlak 2- 1 Hospital Samaritano de São Paulo, Higienópolis, São Paulo, Brazil
- 2 Faculdade Israelita de Ciências da Saúde Albert Einstein Hospital Israelita Albert Einstein, São Paulo, Brazil
- 3 Hospital Amaral Carvalho, Jaú, Brazil
- 4 Hospital Sirio Libanes, São Paulo, São Paulo, Brazil
- 5 National Cancer Institute (INCA), Rio de Janeiro, Rio de Janeiro, Brazil
- 6 Instituto Brasileiro de Controle do Câncer, São Paulo, São Paulo, Brazil
- 7 Federal University of Health Sciences of Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
- 8 Beneficência Portuguesa de São Paulo, Bela Vista, São Paulo, Brazil
- 9 Federal University of Ceara, Fortaleza, Ceará, Brazil
- 10 Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
- 11 Instituto de Cardiologia do Distrito Federal (ICDF), Brasilia, Brazil
- 12 Hospital da Policia Militar, Belo Horizonte, Minas Gerais, Brazil
- 13 Instituto Oncoclínicas, Rio de Janeiro, Paraná, Brazil
- 14 centro hematologia santa catarina, santa catarina, Brazil
- 15 International Center for Research, AC Camargo Cancer Center, São Paulo, São Paulo, Brazil
- 16 Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
- 17 State University of Campinas, Campinas, São Paulo, Brazil
- 18 associação de medula óssea do estado de sao paulo, sao paulo, Brazil
- 19 Federal University of Paraná, Curitiba, Paraná, Brazil
- 20 Center for International Blood and Marrow Transplant Research (CIBMTR), Minneapolis, Minnesota, United States
- 21 Duke University Medical Center, Duke University, Durham, North Carolina, United States
- 22 Fred Hutchinson Cancer Center, Seattle, Washington, United States
This study is the first in a developing country to use the CIBMTR's resources and expertise to analyze local hematopoietic cell transplant results. We have found that, in a developing country with a large donor registry (the REDOME), the results of haploidentical transplantation are not inferior to matched donors in patients in CR1.We have found evidence that the observational comparison has inherent survival bias, limited to patients in CR2+, and neither survival bias nor residual confounding that can't be controlled in the analysis.AS and LJA contributed equally to this work.The authors declare that the study is original, has neither been published before, nor is it under consideration in any other journal.This study was conducted under the declaration of Helsinki.Under a reasonable request, data used in the current analysis will be shared as long as authorized by the CIBMTR.
Keywords: Hematopoietic Cell Transplantation, Survival Bias, Acute Lymphoblastic Leukemia, haploidentical transplantation, Unrelated Donors, matched-related donors, posttransplant cyclophosphamide
Received: 27 Feb 2025; Accepted: 26 Mar 2025.
Copyright: © 2025 Seber, ARCURI, Colturato, SOUZA, Zogbi, Lerner, Macedo, Daudt, Liane Esteves Daudt, Esteves Daudt, Liane, Kerbauy, Gottardello, Duarte, Rabello Chiattone, Soares, Bettarello, Vaz De Macedo, Paton, Monteiro, Schmidt Filho, Astigarraga, Scheinberg, Vigorito, Vergueiro, Simione, Funke, Hashmi, Saber, Patel, Bonfim, Pasquini, Flowers and Hamerschlak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
LEONARDO ARCURI, Faculdade Israelita de Ciências da Saúde Albert Einstein Hospital Israelita Albert Einstein, São Paulo, Brazil
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