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CASE REPORT article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1570355
This article is part of the Research Topic Molecular and Functional Profiling in Breast Cancer: Implications for Hereditary and Sporadic Cases View all articles
Symptomatic bone marrow metastasis in triple-negative breast cancer: a case report
Provisionally accepted- 1 Department of Surgical Oncology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China
- 2 Department of pathology,Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China
Bone metastasis is common in breast cancer, but symptomatic bone marrow involvement is exceedingly rare. This report presents a case of a young female patient with triple-negative breast cancer (TNBC) initially presenting with symptomatic bone marrow metastasis. Upon admission, blood tests revealed severe thrombocytopenia.Bone marrow biopsy confirmed tumor cell infiltration, and immunohistochemistry identified metastatic breast cancer cells. The patient received paclitaxel and eribulin chemotherapy combined with transfusion support, achieving significant symptom control. This rare case highlights the importance of early detection and aggressive management in TNBC with bone marrow metastasis.
Keywords: Symptomatic bone marrow metastasis, Triple-negative breast cancer (TNBC), Advanced breast cancer, case report, Thrombocytopenia, Nutritional Support
Received: 03 Feb 2025; Accepted: 12 Mar 2025.
Copyright: © 2025 Zheng, Dai, Wang, Zheng, Lin and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhibao Zheng, Department of Surgical Oncology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China
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