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REVIEW article
Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1570193
Epigenetic insights into Prostate Cancer: Exploring histone modifications and their therapeutic implications
Provisionally accepted
Bunty Sharma 1 Himanshu Shekhar 2 Anidrisha Sahu 2 Damandeep Kaur 3
Shafiul Haque 4
Hardeep Singh Tuli 5
Dr Himanshu Sharma 6
Ujjawal Sharma 2*- 1 Graphic Era University, Dehradun, Uttarakhand, India
- 2 Central University of Punjab, Bathinda, India
- 3 Chandigarh University, Mohali, Punjab, India
- 4 Jazan University, Jizan, Saudi Arabia
- 5 Maharishi Markandeshwar University, Mullana, Ambala, Haryana, India
- 6 Department of Biochemistry, All India Institute of Medical Sciences, Bathinda (AIIMS Bathinda), Bathinda, Punjab, India
Prostate cancer is one of the most prevalent malignancies globally. This cancerous condition originates within the prostate gland, an integral part of the male reproductive system. The molecular mechanism underlying cancer is among the key areas of research in the scientific community. Cancer, being a multifactorial disease, is controlled by many factors ranging from environmental to genetic to epigenetic factors. Epigenetic regulation holds a crucial role in tumorigenesis and its progression. Epigenetics refers to alterations in the genome that happen without any changes to the DNA sequence itself; they may be triggered by multiple factors ranging from environmental to dietary factors. It includes methylation of DNA and histone modifications, among others. Histone modifications, including histone methylation, histone acetylation, histone ubiquitination, and others, play a crucial role in the pathogenesis and progression of prostate cancer. These epigenetic modifications via transcriptional regulation affect key cellular processes and are thus implicated in prostate cancer and other cancers. These epigenetic marks could be used as both diagnostic as well as prognostic markers and also could be used as novel therapeutic targets against prostate cancer and other malignancies. Here in this review article, we have summarised different histone modifications and their mechanistic and therapeutic implications in prostate cancer.
Keywords: prostate cancer, epigenetics, histone modification, Therapeutics, epigentic modifications
Received: 03 Feb 2025; Accepted: 27 Mar 2025.
Copyright: © 2025 Sharma, Shekhar, Sahu, Kaur, Haque, Tuli, Sharma and Sharma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ujjawal Sharma, Central University of Punjab, Bathinda, India
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.