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CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1563545
Castleman disease of stomach treated by endoscopic submucosal dissection: A case
Provisionally accepted- 1 The Affiliated Hospital of Qingdao University, Qingdao, China
- 2 Qingdao University, Qingdao, Shandong Province, China
BACKGROUND Castleman disease (CD) is a relatively rare benign lymphoproliferative disorder of the lymphoid tissue. According to clinical manifestations, it is classified into two types: unicentric CD (UCD) and multicentric CD (MCD). Pathological subtypes include hyaline-vascular (HV), plasma cell (PC), and mixed (MV). Gastrointestinal CD is extremely rare, and limited information is available regarding its clinical presentation and management.We report a case of a patient who presented with paroxysmal epigastric pain for 4 years. Laboratory tests showed no remarkable abnormalities, whereas CT revealed endogenous occupancy on the side of the greater curvature of the stomach. Ultrasonographic endoscopy demonstrated hypoechoic, well-defined foci. The lesion initially suspected to be an inflammatory fibroma was subsequently pathologically confirmed as HV-UCD following endoscopic submucosal dissection. The lesion was completely resected, and the patient showed no signs of recurrence during 7 months of follow-up. CONCLUSION Gastrointestinal CD is rare and should be differentiated from other occupying lesions. Its definitive diagnosis relies on histopathology.
Keywords: Unicentric Castleman disease, Gastrointestinal Tract, Castleman disease, Endoscopic Submucosal Dissection, histopathology, case report
Received: 20 Jan 2025; Accepted: 19 Mar 2025.
Copyright: © 2025 Sun, Liu, Sun, Shan, Lu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fu-Guo Liu, The Affiliated Hospital of Qingdao University, Qingdao, China
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