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REVIEW article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1557959
This article is part of the Research Topic Gut Microbiota and Local Immune System in Colorectal and Liver Cancer View all articles
Gut Microbiota in Colorectal Cancer: A Review of Its Influence on Tumor Immune Surveillance and Therapeutic Response
Provisionally accepted- Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China
Colorectal cancer (CRC) poses a significant global health burden, with gut microbiota emerging as a crucial modulator of CRC pathogenesis and therapeutic outcomes. This review synthesizes current evidence on the influence of gut microbiota on tumor immune surveillance and responses to immunotherapies and chemotherapy in CRC. We highlight the role of specific microbial taxa in promoting or inhibiting tumor growth and the potential of microbiota-based biomarkers for predicting treatment efficacy. The review also discusses the implications of microbiota modulation strategies, including diet, probiotics, and fecal microbiota transplantation, for personalized CRC management.
Keywords: colorectal cancer, Gut Microbiota, tumor immune surveillance, Therapeutic response, Probiotics, Prebiotics, fecal microbiota transplantation 1. INTRODUCTION
Received: 09 Jan 2025; Accepted: 14 Feb 2025.
Copyright: © 2025 Zhang, Wang, Cheng, Cao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yong Wang, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China
Lei Cheng, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China
Xiansheng Cao, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China
Chunyuan Liu, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China
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