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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1556311
This article is part of the Research Topic Methods and Applications of Tumour Metabolic Imaging in the Preclinical and Clinical Setting View all 7 articles
Amide Proton Transfer-Weighted Imaging Combined with Multiple Models Diffusion-Weighted Imaging of Endometrial Cancer: Correlations between Multi-modal MRI Parameters and HIF-1α Expression
Provisionally accepted
Jun Li 1 Changjun Ma 1,2 Shifeng Tian 1,2
Ailian Liu 1* Qingling Song 1,2 Nan Wang 1,2
Qingwei Song 1,2
Liangjie Lin 3
Peng Sun 3
Jiazheng Wang 3- 1 Department of Radiology, the First Affiliated Hospital of Dalian Medical University,, Dalian, Liaoning Province, China
- 2 Dalian Medical Imaging artificial intelligence engineering technology research center, Dalian, Liaoning Province, China
- 3 Philips (China), Beijing, Beijing Municipality, China
Background ： Hypoxia inducible factor (HIF-1α) is a major transcriptional factor regulating gene expression under hypoxic conditions. HIF-1α expression was closely correlated with the oxygenation status of tumor and could serve as an important biomarker for tumor hypoxia, aggressiveness, or radiation resistance. High expression of HIF-1α contributes to high aggressiveness or poor prognosis of endometrial cancer.Purpose: This study aimed to investigate correlations between multimodal MRI parameters (derived from amide proton transfer weighted imaging [APTw], conventional diffusion weighted imaging [DWI], intravoxel incoherent motion [IVIM] imaging and diffusion kurtosis imaging [DKI]) and HIF-1α expression, and to determine whether multimodal MRI can be used for quantitative evaluation of HIF-1α expression.Population: A total of 94 patients with EC were examined with 32 cases finally included in the high HIF-1α expression group and 40 cases included in the low expression group according to the exclusion and inclusion criteria.
Keywords: DWI, IVIM, HIF-1α, endometrial cancer, Amide proton transfer weighted imaging
Received: 06 Jan 2025; Accepted: 31 Mar 2025.
Copyright: © 2025 Li, Ma, Tian, Liu, Song, Wang, Song, Lin, Sun and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ailian Liu, Department of Radiology, the First Affiliated Hospital of Dalian Medical University,, Dalian, Liaoning Province, China
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