REVIEW article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1555274
Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways
Provisionally accepted
- Heilongjiang University of Chinese Medicine, Harbin, China
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Precancerous lesions of the stomach (PLGC), a critical stage in gastric cancer development, have garnered significant attention for its prevention and treatment. PLGC refers to a series of pathological and histological changes preceding cancer. Due to its complex pathogenesis and multi-factor influence, no currently existing drug can effectively prevent or delay this process. Therefore, identifying a safe and effective treatment method remains an important research focus. In recent years, traditional Chinese medicine has demonstrated unique advantages and potential in PLGC treatment. Many studies have focused on the regulation of traditional Chinese medicine's active ingredients on relevant signaling pathways. Studies show active ingredients can regulate cell proliferation, apoptosis, differentiation, autophagy, oxidative stress, and inflammatory response via multi-target, multi-pathway intervention of key signaling pathways like hypoxia-inducible factor 1 (HIF-1α), nuclear factor kappa-B (NF-κB), wingless-type MMTV integration site family/ betacatenin (Wnt/β-catenin), phosphoinositide 3-kinases/Protein kinase B (PI3K/AKT), Sonic Hedgehog (Shh), Janus kinase/signal transducer and activator of transcription (JAK/STAT), mitogen-activated protein kinase (MAPK), nuclear factor erythroid 2-related factor 2 (Nrf2), and more, thereby delaying or reversing PLGC progression. This paper summarizes and sorts research on the regulation of these pathways by traditional Chinese medicine's active ingredients, seeking to provide a theoretical basis and medication reference for PLGC treatment with traditional Chinese medicine.
Keywords: gastric precancerous lesions1, Signaling pathway2, traditional Chinese medicine3, active ingredients4, research progress5
Received: 04 Jan 2025; Accepted: 15 Apr 2025.
Copyright: © 2025 Han, Ma, Wu, Ni, Xie, Huang, Jin, Wu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yang Zhang, Heilongjiang University of Chinese Medicine, Harbin, China
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