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REVIEW article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1554179
This article is part of the Research Topic Hot Topics in Cell Death: Circular and Non-Coding Endogenous RNA in Cancer Progression View all 3 articles
Circular RNAs perspective: exploring the direction of immunotherapy for colorectal cancer
Provisionally accepted- Central South University, Changsha, China
Circular RNAs (circRNAs) are multifaceted molecules that play a pivotal role in regulating gene expression at both transcriptional and post-transcriptional levels. Their expression is highly tissue-specific and developmentally regulated, making them critical players in various physiological processes and diseases, particularly cancer. In colorectal cancer, circRNAs exhibit significantly dysregulated expression patterns and profoundly influence disease progression through diverse molecular mechanisms. Unraveling the complex roles of circRNAs in modulating colorectal cancer immunotherapy outcomes highlights their potential as both promising biomarkers and therapeutic targets. Moving forward, advancements in circRNA-based therapeutic strategies and delivery systems are poised to transform precision medicine, enabling early colorectal cancer diagnosis and improving patient prognosis.
Keywords: circular RNA, colorectal cancer, Immunotherapy, diagnosis, precision medicine
Received: 01 Jan 2025; Accepted: 24 Mar 2025.
Copyright: © 2025 Cao, He, Liao and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lingshan Liao, Central South University, Changsha, China
Lixin Xu, Central South University, Changsha, China
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