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REVIEW article
Front. Oncol.
Sec. Pediatric Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1553511
This article is part of the Research Topic Novel Molecular Targets and Therapies for Pediatric Extracranial Solid Tumors View all 6 articles
Emerging clinical and research approaches in targeted therapies for high-risk neuroblastoma
Provisionally accepted- University of California, Davis, Davis, United States
Neuroblastoma is a pediatric cancer that originates from neural crest cells and is the most common extracranial solid tumor in children under five years of age. While low-risk neuroblastoma often regresses spontaneously, high-risk neuroblastoma poses a significant clinical challenge. Recent advances in understanding neuroblastoma's molecular mechanisms have led to the development of targeted therapies that aim to selectively inhibit specific pathways involved in tumor growth and progression, improving patient outcomes while minimizing side effects. This review provides a comprehensive review of neuroblastoma biology and emerging therapeutic strategies. Key topics include (a) immunotherapies and immunotargets, (b) non-coding RNAs (long non-coding RNA, microRNA, and circular RNA), (c) molecular biomarkers and pathways, and (d) limitations and future directions.
Keywords: High-risk neuroblastoma, Neuroblastoma biology, targeted therapy, pediatric cancer, Clinical and preclinical research
Received: 30 Dec 2024; Accepted: 06 Feb 2025.
Copyright: © 2025 AlKhazal, Chohan, Ross, Kim and Brown. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Samiha Chohan, University of California, Davis, Davis, United States
Destani J Ross, University of California, Davis, Davis, United States
Jinhwan Kim, University of California, Davis, Davis, United States
Erin G Brown, University of California, Davis, Davis, United States
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.