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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1553248
This article is part of the Research TopicNovel Molecular Targets in Cancer TherapyView all 28 articles
Correlation of heat shock protein 1 expression with progression and prognosis of non-small cell lung cancer
Provisionally accepted
Rui Wang1,2
Rongqi Guo2
Tianyi Huang1Yu Lu1
Weisong Zhang2Yihao Wang2
Qinggan Ni3*Jianxiang Song1,2*
Xia Li4*- 1Nantong University, Nantong, China
- 2Department of Cardiothoracic Surgery, Yancheng Third People’s Hospital, Yancheng, Jiangsu Province, China
- 3Yancheng First People's Hospital, Yancheng, Jiangsu, China
- 4Yancheng Third People's Hospital, Yancheng, China
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Aims: To investigate the expression and clinical significance of heat shock protein H1 (HSPH1) in non-small cell lung cancer (NSCLC). To provide new and reliable biomarkers for the treatment of NSCLC. Main methods: Various public databases were used to analyse the molecular characteristics, disease relevance and expression differences of HSPH1 and to investigate the correlation between HSPH1 expression and prognosis in NSCLC patients. MsigDB and Molecular signatures database were used for enrichment analysis. The HSPH1 protein interaction network was constructed using the STRING database. In addition, immune infiltration analysis was performed. Subsequently, the expression levels of HSPH1 in Lung cancer cell lines, human NSCLC tissues and normal tissues were determined using various experiments. Finally, a retrospective analysis was performed to determine whether the expression level of HSPH1 was associated with the clinical characteristics and prognosis of NSCLC patients. Results: The high expression of HSPH1 in NSCLC was significantly correlated with the clinical characteristics and poor prognosis of patients, and it may affect the progression of NSCLC by forming a regulatory network with molecules such as HSPA8, BAG2, etc., and its mechanism may involve the regulation of the P53 signalling pathway, G2M_CHECKPOINT and mTORC1_SGNALING. Experiments confirmed that HSPH1 was also highly expressed in NSCLC tissues and cells. Conclusion: HSPH1 can be used as a potential diagnostic and prognostic marker for NSCLC, and its involvement in NSCLC progression and immune regulation may be one of its therapeutic targets.
Keywords: HSPH1, NSCLC, biomarker, Bioinformatics analysis, prognosis, progression
Received: 30 Dec 2024; Accepted: 14 Apr 2025.
Copyright: © 2025 Wang, Guo, Huang, Lu, Zhang, Wang, Ni, Song and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qinggan Ni, Yancheng First People's Hospital, Yancheng, 224001, Jiangsu, China
Jianxiang Song, Department of Cardiothoracic Surgery, Yancheng Third People’s Hospital, Yancheng, Jiangsu Province, China
Xia Li, Yancheng Third People's Hospital, Yancheng, China
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