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SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1552914
This article is part of the Research Topic Precision Medicine and Targeted Therapies in Gastrointestinal and Genitourinary Solid Tumors View all 7 articles
Advances in bevacizumab in colorectal cancer: a bibliometric analysis from 2004 to 2023
Provisionally accepted- Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, China
Background: Bevacizumab is a primary focus in the clinical application and research of metastatic colorectal cancer (mCRC) patients. This study aims to analyze publications on bevacizumab and CRC to explore and identify the trends and frontiers of this field.We collected 4,164 articles on bevacizumab and CRC from the Web of Science Core Collection (WoSCC). CiteSpace, VOSviewer, R-bibliometrix, and Microsoft Excel were utilized for analysis and visualization.The United States, Japan, and China are the leading countries in this field. The National Cancer Institute and the University of Pisa share the top position for the highest number of publications. Personalized therapy, innovative combination treatments, mechanisms of resistance, and new drug development are enduring focal points and future research directions.This study provides the first bibliometric analysis of research on bevacizumab and CRC, revealing the current status and future directions of this field.
Keywords: bevacizumab, colorectal cancer, Citespace, VOSviewer, bibliometric analysis
Received: 29 Dec 2024; Accepted: 10 Mar 2025.
Copyright: © 2025 Chen, Lei, Zhou, Lv and Xuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qijia Xuan, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.