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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1552193
Imaging and Pathological Characteristics of Hepatosplenic EBV-Positive Inflammatory Follicular Dendritic Cell Sarcoma
Provisionally accepted
Yang-Yang Chen1Peng-Ming Wang1Li-Zhu Deng2Pei-Heng Li1Chen-Guang Li1Yu-Hua He1Feng Chen3
Jun-Yan Yue1*- 1The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China
- 2Zhongshan Hospital, Xiamen University, Xiamen, Fujian Province, China
- 3First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
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Background: The aim of this study is to explore the CT and MRI characteristics of hepatosplenic Epstein-Barr virus (EBV)-positive inflammatory follicular dendritic cell sarcoma (IFDCS) and to correlate these findings with pathological characteristics to enhance diagnostic understanding.Case description: A retrospective analysis was conducted on 16 patients with surgically confirmed hepatosplenic EBV-positive IFDCS, who underwent CT and MRI between January 2015 and May 2024. Clinical, pathological, and imaging data were evaluated.Results: Hepatosplenic EBV-positive IFDCS primarily occurred in middle-aged adults, with a greater prevalence in females. All cases presented as solitary, well-defined masses, either round or oval in shape. Calcification was noted in one case, while necrosis and cystic degeneration were observed in nine cases. Contrast-enhanced CT and MRI showed that 15 cases exhibited heterogeneous, mild to moderate persistent uneven enhancement of the tumor parenchyma, with most lesions appearing hypodense or hypointense in the delayed phase. The majority of cases showed a hypodense or hypointense capsule with delayed enhancement. Solid tumor components appeared hyperintense on diffusion-weighted imaging (DWI), with apparent diffusion coefficient values similar to those of the spleen. One case of hepatic EBV-positive IFDCS exhibited an atypical enhancement pattern characterized by rapid wash-in and slow wash-out. Conclusion: MRI proved superior in visualizing the tumor capsule and providing qualitative diagnostic information, yielding crucial information for clinical diagnosis and preoperative evaluation.
Keywords: EBV-positive, Imaging features, inflammatory follicular dendritic cell sarcoma, Liver, Spleen
Received: 27 Dec 2024; Accepted: 10 Apr 2025.
Copyright: © 2025 Chen, Wang, Deng, Li, Li, He, Chen and Yue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jun-Yan Yue, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China
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