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CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1550917
This article is part of the Research TopicEnhancing outcomes in colorectal cancer: Multidisciplinary approaches to therapy and pain managementView all articles
Squamous cell carcinoma of the small intestine: A case report and review of literature
Provisionally accepted- 1Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
- 2Department of Oncology & Cancer Institute, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China
- 3Yu-Yue Pathology Scientific Research Center, Chongqing, China
- 4JinFeng Laboratory, Chongqing, China
- 5Department of Pathology, Southwest Hospital, Army Medical University, Chongqing, China
- 6Department of Oncology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China, Chengdu, China
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Malignant tumors derived from the small intestine are rare, and most are adenocarcinomas. Primary squamous cell carcinoma of the small intestine is sporadic with a few cases reported in the literature. This study reports a case of a 56-year-old female who had a history of leakage of exudate for more than 40 years after an appendectomy. The patient presented with increasing leakage of exudate, abdominal pain, and fever this time, and was diagnosed with primary squamous cell carcinoma of the ileal after an intestinal resection and a fascial plasty. The patient declined to receive adjuvant chemotherapeutic treatment and died 9 months after the diagnosis of the tumor. Additionally, we reviewed 26 reported cases, summarized the clinical features and treatments, and discussed the potential pathogenesis and optional therapeutic strategies for primary squamous cell carcinoma of the small intestine.
Keywords: Squamous cell carcinoma, small intestine, Clinical feature, Treatment, Pathogenesis
Received: 24 Dec 2024; Accepted: 10 Apr 2025.
Copyright: © 2025 Wang, Li, Hu, Wang, Xu and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ying Wang, Department of Oncology & Cancer Institute, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, 611731, Sichuan Province, China
Senlin Xu, Department of Pathology, Southwest Hospital, Army Medical University, Chongqing, 400038, China
Chuan Xu, Department of Oncology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.