94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1549809
A viral infection prediction model for r/r B-cell malignances patients after CAR-T therapy: a retrospective analysis
Provisionally accepted
Shujing Guo 1
Jile Liu 1
Wang Bing 2 Xiaomei Zhang 3
Yifan Zhao 1 Jianmei Xu 4
Xinping Cao 1 Mohan Zhao 1
Xia Xiao 2*
Mingfeng Zhao 2*- 1 Tianjin Medical University, Tianjin, China
- 2 Tianjin First Central Hospital, Tianjin, China
- 3 Nankai University, Tianjin, China
- 4 Hebei University Affiliated Hospital, baoding, China
Background: Chimeric antigen receptor T cell (CAR-T) for relapsed/refractory (r/r) B cells acute lymphoblastic leukemia (B-ALL) and B cells non-Hodgkin lymphoma (B-NHL) patients has shown promising effects, but side effects such as viral infections have been observed.Methods: A total of 45 r/r B-ALL and r/r B-NHL patients were included in this retrospective study. Patient demographics were recorded, with the primary endpoint being viral infection within three months post CAR-T treatment. Univariate, multivariate logistic regression analysis, and lasso (95% CI 0.837-1.000) and 0.869 (95%CI 0.696-1.000) respectively, which had excellent predictive value.We established a nomogram to predict the factors influence on viral infection CAR-T and found that ratio of baseline lymphocyte and using G-CSF early or lately were screened to be able to predict viral
Keywords: refractory/relapsed B cell malignances, chimeric antigen receptor T cells, predictive models, viral infection, Granulocyte Colony-Stimulating Factor
Received: 22 Dec 2024; Accepted: 24 Feb 2025.
Copyright: © 2025 Guo, Liu, Bing, Zhang, Zhao, Xu, Cao, Zhao, Xiao and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xia Xiao, Tianjin First Central Hospital, Tianjin, China
Mingfeng Zhao, Tianjin First Central Hospital, Tianjin, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.