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REVIEW article
Front. Oncol.
Sec. Cancer Metabolism
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1549797
This article is part of the Research Topic Synthetic Biology and Metabolomics: Novel Insight in Oncology Research View all 4 articles
The role of various collagen types in tumor biology: a review
Provisionally accepted- 1 Department of oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
- 2 Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
Collagen comprises approximately 30% of the body's protein content and is essential for maintaining the structural integrity, support, and strength of the skin, muscles, bones, and connective tissues. Recent research has further elucidated its role in various aspects of tumor biology, including tumorigenesis, invasion, migration, drug resistance, and recurrence. Furthermore, collagen is involved in prognostic assessments, the evaluation of therapeutic efficacy, immunoregulation, and the identification of potential treatment targets in oncology. This review examines a range of tumor types, including lung, gastric, breast, melanoma, and colorectal cancers, among others. Our objective is to differentiate these tumors based on the specific types of collagen present and to analyze the roles of various collagen types in tumor development, progression, prognosis, and their potential as therapeutic targets.
Keywords: Collagen, Cancer, review, Collagen 1, theraputic target
Received: 22 Dec 2024; Accepted: 17 Feb 2025.
Copyright: © 2025 Zhou, Jiang, Cao and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jianquan Yang, Department of oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
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