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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1549148
This article is part of the Research TopicEarly Diagnosis in Head and Neck Cancer: Advances, Techniques, and ChallengesView all 6 articles
Construction of a predictive model for cervical lymph node metastasis in papillary thyroid carcinoma
Provisionally accepted- 1Department of Ultrasound, First Hospital of Shanxi Medical University, Shanxi, China
- 2First Hospital of Shanxi Medical University, Taiyuan, China
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In oncology, the relationships among cervical central lymph node metastasis (CLNM), biochemical tests, and ultrasound characteristics in patients with papillary thyroid cancer (PTC) remain controversial. This association is currently not well supported by evidence, which emphasizes the need for further research.Understanding the connection between CLNM, biochemical testing, and ultrasound features is crucial for clinical practice and public health efforts. Research on this topic is still underway and is now receiving much interest. Our goal was to create and verify a basic cervical lymph node metastasis prediction model.: In this retrospective cohort study, 685 individuals diagnosed with PTC from the First Hospital of Shanxi Medical University (n = 560) and Changzhi Heping Hospital (n = 125) participated in the research from January 2020 to October 2022. characteristic (ROC) curves, decision curve analysis, and calibration curves were used to assess the predictive accuracy, clinical utility, and discriminative ability of the nomogram.Results: Of the 560 individuals, 54.3% (304/560) did not have lymph node metastases, whereas 45.7% (256/560) did. Age, male, nodule size, multifocal lesions, capsular contact or invasion and ill-defined margins were determined to be risk variables via BSR and multivariate logistic analysis. Nomograms were created using these six risk indicators. The prediction model of CLNM had an AUC of 0.884 (95% CI 0.851, 0.916).Both the internal and the external validation results were highly encouraging.Confirming the model's stability and applicability in different data environments.We developed a predictive model and nomogram for CLNM in PTC patients, which demonstrated robust performance. This model can guide surgical planning, potentially reducing complications and improving outcomes.
Keywords: Papillary thyroid cancer, lymph node metastasis, Risk factors, predictive model, Nomograms
Received: 20 Dec 2024; Accepted: 07 Apr 2025.
Copyright: © 2025 Hao, Su and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liping Liu, First Hospital of Shanxi Medical University, Taiyuan, China
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