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REVIEW article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1548036
A Case of High-Grade Adenosquamous Carcinoma of the Breast: Case Report and Literature Review
Provisionally accepted- Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
High-grade adenosquamous carcinoma (HGASC) is a rare and aggressive subtype of metaplastic breast cancer (MpBC). This article reports a case of HGASC (pT2N0M0 Stage IIA) in a 43-year-old female and reviews the relevant literature, with a specific focus on distinguishing HGASC from other MpBC subtypes, particularly low-grade adenosquamous carcinoma (LGASC). The patient underwent a skin-sparing mastectomy with abdominal rectus myocutaneous flap reconstruction.Histopathology confirmed HGASC with metaplastic features. Postoperative adjuvant chemotherapy with capecitabine was administered. The case highlights the unique clinical, imaging, and pathological characteristics of HGASC, its therapeutic challenges, and the need for individualized treatment strategies. A five-month follow-up showed no signs of recurrence or metastasis.
Keywords: High-grade adenosquamous carcinoma, Metaplastic breast cancer, case report, Breast cancer surgery, Adjuvant chemotherapy
Received: 19 Dec 2024; Accepted: 13 Feb 2025.
Copyright: © 2025 Xing, Li, Fan, Wang, Wang, Liao and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Junyi Li, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Yangyang Fan, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Yun Wang, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Yue Wang, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Daixiang Liao, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Shiyun Zhang, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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