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CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 |
doi: 10.3389/fonc.2025.1547258
Case report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient
Provisionally accepted
Olivia C. Ghirardelli Smith 1
Alexander K. Tsai 1
Minghao Zhong 2* Pegah Dejban 2,3* Andrew C. Nelson 2*
Michelle Dolan 2 Emmanuel S. Antonarakis 1*
Paari Murugan 2*- 1 Department of Medicine, Division of Hematology, Oncology & Transplantation, University of Minnesota, Minneapolis, United States
- 2 Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, United States
- 3 Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, Michigan, United States
We report for the first time a case of a postpubertal patient presenting with a metastatic prepubertal-type testicular teratoma.A 29-year-old male with a history of corrected unilateral cryptorchidism presented with progressive bilateral lower extremity edema. Imaging revealed an inferior vena cava thrombus associated with a complex mass. A left testicular ultrasound identified a solid lesion suggestive of a germ cell tumor, leading to a left radical orchiectomy, which revealed a mature pure teratoma with no evidence of germ cell neoplasia in situ (GCNIS). Excision of the retroperitoneal mass confirmed the presence of mature teratomatous elements without evidence of non-teratomatous germ cell tumor elements or cytological atypia. Fluorescence in situ hybridization (FISH) showed no evidence of gain of 12p, and next-generation sequencing showed no alterations in genes known to be associated with GCT.This case illustrates that pure mature teratomas lacking chromosome 12p abnormalities, GCNIS, and other dysgenetic features, occurring in postpubertal males, cannot invariably be classified into the benign prepubertal-type teratoma category. Contrary to current paradigm, in rare cases these may represent tumors with metastatic potential.
Keywords: Germ Cell Neoplasia in Situ (GCNIS), germ cell tumor (GCT), prepubertal-type teratoma, postpubertal-type teratoma, Isochromosome 12p (i12p), testicular cancer
Received: 18 Dec 2024; Accepted: 27 Jan 2025.
Copyright: © 2025 Ghirardelli Smith, Tsai, Zhong, Dejban, Nelson, Dolan, Antonarakis and Murugan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Minghao Zhong, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, United States
Pegah Dejban, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, United States
Andrew C. Nelson, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, United States
Emmanuel S. Antonarakis, Department of Medicine, Division of Hematology, Oncology & Transplantation, University of Minnesota, Minneapolis, United States
Paari Murugan, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, United States
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