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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1543055
This article is part of the Research TopicMultidisciplinary Management of Oral Cancer: Diagnosis, Treatment, and RehabilitationView all 7 articles
Combined CA125, NSE, and multiple inflammatory indices for diagnosis of oral squamous cell carcinoma
Provisionally accepted- People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang Uyghur Region, China
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Objective: To investigate the changes of serum carbohydrate antigen 125 (CA125), neuron-specific enolase (NSE), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic inflammation response index (SIRI) in patients with oral squamous cell carcinoma(OSCC) and their diagnostic value for OSCC.Subjects and Methods: A retrospective analysis was conducted on 136 patients with oral squamous cell carcinoma (OSCC) and 34 healthy controls. Blood routine parameters, as well as serum levels of CA125 and NSE, were obtained for the patients. Additionally, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic inflammation response index (SIRI) were calculated. The diagnostic value of each marker, both individually and in combination, was evaluated using receiver operating characteristic (ROC) curve analysis.Results: We found that the levels of CA125, NSE, NLR, PLR, and SIRI in the oral squamous cell carcinoma group were significantly higher than those in the healthy control group (PCA125<0.001, PNSE=0.004, PNLR=0.034, PPLR=0.035, PSIRI=0.012). Significant differences were observed in NLR, PLR, and SIRI with respect to the size of the primary tumor and local lymph node involvement, as well as substantial differences in NLR and SIRI with distant metastasis (P<0.05). When NLR, PLR, and SIRI were combined with CA125 and NSE, the area under the curve (AUC) significantly increased (P<0.05). Further analysis using Delong's test revealed a statistically significant difference in AUC values, suggesting that the combined diagnostic approach was more effective than individual markers.: The diagnosis efficiency of OSCC can be enhanced by combining CA125, NSE, NLR, PLR, Co-Diagnosis of OSCC 2and SIRI. This combined approach offers high sensitivity and specificity for early diagnosis.
Keywords: Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic inflammation response index, Carbohydrate antigen 125, neuron-specific enolase, Oral squamous cell carcinom, diagnostic value
Received: 10 Dec 2024; Accepted: 15 Apr 2025.
Copyright: © 2025 Abudukelimu, Tuerxuntayi, aierken, Keranmu and wufuer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Duolikun wufuer, People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, 830001, Xinjiang Uyghur Region, China
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