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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1542463
HALP Score as a Prognostic Marker for Overall Survival in Advanced Pancreatic Cancer
Provisionally accepted
Nazan Demir 1*
İvo Gökmen 2
Yasemin Sağdıç Karateke 3 Ayşegül İlhan 4 Fatih Yıldız 5 Duygu Bayır Garbioğlu 6 Bülent Yıldız 3- 1 Sultan I. Murat Public Hospital, Edirne, Türkiye
- 2 Çanakkale Mehmet Akif Ersoy State Hospital, Çanakkale, Çanakkale, Türkiye
- 3 Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Eskişehir, Türkiye
- 4 Ankara Etlik City Hospital, Ankara, Ankara, Türkiye
- 5 Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Ankara, Türkiye
- 6 Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Zonguldak, Türkiye
ABSTRACTIntroduction: Pancreatic cancer is the leading cause of cancer-related deaths worldwide and most of the patients diagnosed at an advanced stage. Clinicians need simple, effective, and repeatable tools to predict the prognosis. This study aimed to evaluate the relationship between the HALP score and prognosis in patients with advanced pancreatic cancer.Methods: Patients diagnosed with advanced pancreatic cancer at three centers in Turkey between 2009 and 2023 were included in this retrospective study. Demographic features, blood parameters, treatment received, treatment responses, and survival were recorded.Results: 227 patients were included in the study. The median overall survival (OS) for the entire cohort was 10.4 months. The median OS was 8.7 months in the low-HALP group and 11.2 months in the high- HALP group. Patients in the low-HALP group had a significantly shorter median OS than those in the high-HALP group (log rank p=0.001). Conclusion: The HALP score is a reliable and practical tool that can be utilized in clinical practice to predict prognosis in patients with advanced pancreatic cancer.Keywords: HALP score, overall survival, advanced pancreatic cancer, gastrointestinal cancers, prognostic index
Keywords: Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers Data curation, Formal analysis, Software, Writing -review & editing. Fatih Yıldız: Data curation, methodology, Writing -original draft. Bülent Yıldız: Supervision, visualization, Writing -review & editing. Duygu Bayır Garbioğlu: Data curation
Received: 09 Dec 2024; Accepted: 31 Mar 2025.
Copyright: © 2025 Demir, Gökmen, Sağdıç Karateke, İlhan, Yıldız, Bayır Garbioğlu and Yıldız. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Nazan Demir, Sultan I. Murat Public Hospital, Edirne, Türkiye
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