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CASE REPORT article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1539671
Two Cases of Atypical Neurofibroma Neoplasm of Uncertain Biological Potential in the Nasal Cavity and a Literature Review
Provisionally accepted- 1 Department of Otorhinolaryngology & Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China
- 2 Department of Operating Room, The Affiliated Hospital of Qingdao University, Qingdao, China
Objective: This study aims to investigate the clinical diagnosis, treatment processes, and pathological characteristics of two cases of atypical neurofibroma neoplasm of uncertain biological potential (ANNUBP) located in the nasal cavity.We retrospectively analyzed the medical history, imaging studies, pathological results, and follow-up data of two patients diagnosed with nasal ANNUBP who were admitted to Qingdao University Hospital between June and October 2023. A review of relevant literature was conducted to summarize their clinical characteristics, diagnosis, treatment, and prognosis.Results: Both patients underwent surgical treatment, with one receiving postoperative radiotherapy. Follow-up evaluations indicated that both patients experienced satisfactory recovery, with no signs of local recurrence or distant metastasis.ANNUBP is a recently recognized and rare subtype of neurogenic tumor. Surgical intervention is regarded as an effective treatment method. This study adhered to established treatment principles for nasal tumors and achieved satisfactory outcomes through surgical intervention and diligent postoperative follow-up.
Keywords: Atypical neurofibroma of uncertain biological potential, Nasal Cavity, Malignant peripheral nerve sheath tumor, neurofibromatosis type 1, Neurofibroma
Received: 04 Dec 2024; Accepted: 28 Mar 2025.
Copyright: © 2025 Zhang, Pang, Chen, Jiang, Zhao, Fu and Wen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Min Chen, Department of Otorhinolaryngology & Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China
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