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CASE REPORT article
Front. Oncol.
Sec. Radiation Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1539309
This article is part of the Research Topic Exploring Molecular Mechanisms in Cancer through Tumor Molecular Pathology View all articles
Metastatic INI-1-deficient undifferentiated lung cancer with EGFR 19del mutation identified in pleural effusion: a case report and review of the literature
Provisionally accepted- 1 Liaocheng People's Hospital, Liaocheng, China
- 2 Shenxian People’s Hospital, liaocheng, China
INI-1 is a core component of the switch/sucrose-non-fermenting (SWI/SNF) complex, an ATP-dependent chromatin remodeling complex that plays a critical role in DNA repair, transcriptional regulation, and cellular differentiation. Intrathoracic tumors driven by INI-1 inactivation are exceptionally rare. This report presents the first documented case of metastatic INI-1-deficient undifferentiated lung cancer harboring a co-occurring epidermal growth factor receptor (EGFR) exon 19 deletion mutation. The clinical and pathological characteristics of the tumor are described, followed by a comprehensive review of the relevant literature.
Keywords: INI-1, lung cancer, EGFR 19del mutation, SWI/SNF complex, INI-1-deficient undifferentiated lung cancer
Received: 04 Dec 2024; Accepted: 24 Mar 2025.
Copyright: © 2025 Guo, Li and Duan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiufang Duan, Shenxian People’s Hospital, liaocheng, China
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