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REVIEW article
Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 15 - 2025 |
doi: 10.3389/fonc.2025.1536779
This article is part of the Research Topic Advances in Intelligence or Nanomedicine-based Theranostics for Cancers View all articles
From Detection to Elimination: Iron-Based Nanomaterials Driving Tumor Imaging and Advanced Therapies
Provisionally accepted- Ningbo Yinzhou People's Hospital, Ningbo, Zhejiang Province, China
Iron-based nanomaterials (INMs), due to their particular magnetic property, excellent biocompatibility, and functionality, have been developed into powerful tools in both tumor diagnosis and therapy. We give an overview here on how INMs such as iron oxide nanoparticles, element-doped nanocomposites, and iron-based organic frameworks (MOFs) display versatility for tumor imaging and therapy improvement. In terms of imaging, INMs improve the sensitivity and accuracy of techniques such as magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) and support the development of multimodal imaging platforms. Regarding treatment, INMs play a key role in advanced strategies such as immunotherapy, magnetic hyperthermia, and synergistic combination therapy, which effectively overcome tumor-induced drug resistance and reduce systemic toxicity. The integration of INMs with artificial intelligence (AI) and radiomics further expands its capabilities for precise tumor identification, and treatment optimization, and amplifies treatment monitoring. INMs now link materials science with advanced computing and clinical innovations to enable next-generation cancer diagnostics and therapeutics.
Keywords: Iron-based nanomaterials, tumor imaging, magnetic hyperthermia, Immunotherapy, artificial intelligence
Received: 29 Nov 2024; Accepted: 16 Jan 2025.
Copyright: © 2025 Xie, Wu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qiang Li, Ningbo Yinzhou People's Hospital, Ningbo, Zhejiang Province, China
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