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CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1536411
Renal cell carcinoma of the native kidney in renal transplant recipients: case series and literature review
Provisionally accepted- West China Hospital, Sichuan University, Chengdu, China
Kidney transplant recipients (KTRs) carry an elevated risk of cancer-related mortality. The cumulative incidence of de novo post-transplant malignancy (DPTM) reaches 10% at 10 years, with renal cell carcinoma (RCC) arising in native kidneys being the predominant urologic malignancy.This study presents three KTRs who developed native kidney RCC 6-15 years post-transplantation.Notably, Case 1 demonstrated a 14.7 cm mass at diagnosis, secondary to non-adherence to protocolbased native kidney surveillance. Histopathological confirmation of RCC was established in all cases through ISUP/WHO-graded surgical specimens and immunophenotypic profiling.KTRs exhibit elevated native kidney RCC risk, often with nonspecific clinical presentations. Our findings emphasize the critical role of systematic imaging protocols, particularly ultrasonography and contrast-enhanced ultrasound (CEUS), in early tumor detection. Implementing these strategies may improve survival and reduce disease burden in this high-risk population. re 2 Renal cell carcinoma in renal transplant recipients
Keywords: Renal cell carcinoma, Kidney, Transplantation, ultrasound, diagnosis, case report
Received: 28 Nov 2024; Accepted: 04 Apr 2025.
Copyright: © 2025 Tao, Wang, Peng and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiaojiao Zhou, West China Hospital, Sichuan University, Chengdu, China
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