ORIGINAL RESEARCH article

Front. Oncol.

Sec. Cancer Epidemiology and Prevention

Volume 15 - 2025 | doi: 10.3389/fonc.2025.1533756

This article is part of the Research TopicCancer Epidemiology and Etiology Evaluation in Latin American PopulationView all 3 articles

GATA3 Germline Variants in Childhood pre-B Acute Lymphoblastic Leukemia: Association with CRLF2 Overexpression and Overweight in Mexican Patients

Provisionally accepted
Adriana Reyes-LeónAdriana Reyes-León1Eduardo Castro-VargasEduardo Castro-Vargas2Ma. del Rocío Juárez-VelázquezMa. del Rocío Juárez-Velázquez1Daniel Martinez AnayaDaniel Martinez Anaya1Consuelo Salas-LabadíaConsuelo Salas-Labadía1Dafné Moreno-LorenzanaDafné Moreno-Lorenzana3Cesar Alejandro Galvan DiazCesar Alejandro Galvan Diaz4Norma López-SantiagoNorma López-Santiago5Eduardo García-PadillaEduardo García-Padilla2Alda Daniela GarciaAlda Daniela Garcia4Isabel Medina-VeraIsabel Medina-Vera6Patricia Pérez-VeraPatricia Pérez-Vera1*
  • 1Laboratorio de Genética y Cáncer. Instituto Nacional de Pediatría, México, Mexico
  • 2Laboratorio de Genética y Cáncer. Becario de la Dirección General de Calidad y Educación en Salud, Secretaría de Salud., México, Mexico
  • 3CONAHCYT-Instituto Nacional de Pediatría, México, Mexico
  • 4Servicio de Oncología. Instituto Nacional de Pediatría, México, Mexico
  • 5Servicio de Hematología. Instituto Nacional de Pediatría, México, Mexico
  • 6Departamento de Metodología de la Investigación. Instituto Nacional de Pediatría, México, Mexico

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CRLF2 abnormalities are prevalent in Hispanics from the U.S. and Mexican children with pre-B acute lymphoblastic leukemia (ALL). This trait is associated with unfavorable prognosis. Furthermore, SNPs rs3824662 and rs3781093 in GATA3 have been associated with an increased risk of pre-B ALL. In particular, rs3824662 is associated with CRLF2-ALL, with a higher prevalence in Hispanic patients. Additionally, rs3824662 is associated with adipogenesis, since Hispanic patients have a high prevalence of obesity and overweight, it has been suggested that obesity predisposes to CRLF2-ALL. In this study, we evaluated rs3824662 and rs3781093 as predisposition markers for pre-B ALL in Mexican children. Both risk alleles were found to be associated with susceptibility to pre-B ALL, predisposition to CRLF2-ALL, overweight status, and overall survival. The risk alleles of both SNPs in Mexican patients were among the most frequent compared with other non-Amerindian populations. SNP rs3824662 and rs3781093 were informative for the Mexican population. Analysis of nutritional status indicated that GATA3 alleles may impact overweight status. Further studies on the relationship between nutritional status and GATA3, as well as analysis of other Amerindian ALL populations, are recommended.

Keywords: Pre-B acute lymphoblastic leukemia, Mexicans, Children, Overweight, Obesity, CRLF2 overexpression, SNPs in GATA3

Received: 24 Nov 2024; Accepted: 10 Mar 2025.

Copyright: © 2025 Reyes-León, Castro-Vargas, Juárez-Velázquez, Martinez Anaya, Salas-Labadía, Moreno-Lorenzana, Galvan Diaz, López-Santiago, García-Padilla, Garcia, Medina-Vera and Pérez-Vera. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Patricia Pérez-Vera, Laboratorio de Genética y Cáncer. Instituto Nacional de Pediatría, México, Mexico

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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