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REVIEW article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1532924
This article is part of the Research Topic Cancer Biomarkers: Molecular Insights into Diagnosis, Prognosis, and Risk Prediction View all 14 articles
Prognostic and predictive molecular biomarkers in colorectal cancer
Provisionally accepted- 1 Medical School, Nanjing University, Nanjing, China
- 2 Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
- 3 Jiangsu University, Zhenjiang, Jiangsu Province, China
- 4 Nanjing Drum Tower Hospital, Nanjing, Jiangsu Province, China
Precision medicine has brought revolutionary changes to the diagnosis and treatment of cancer patients, and is currently a hot and challenging research topic. Currently, the treatment regimens for most colorectal cancer (CRC) patients are mainly determined by several biomakers, including Microsatellite Instability(MSI), RAS, and BRAF. However, the roles of promising biomarkers such as HER-2, consensus molecular subtypes (CMS), and circulating tumor DNA (ctDNA) in CRC are not yet fully clear. Therefore, it is urgent to explore the potential of these emerging biomarkers in the diagnosis and treatment of CRC patients. In this paper, we discuss recent advances in CRC biomarkers, especially clinical data, and focus on the roles of biomarkers in prognosis, prediction, treatment strategies, and the intrinsic connections with clinical pathological features, hoping to promote better precision medicine for colorectal cancer.
Keywords: colorectal cancer, biomarkers, circulating tumor DNA, non-coding RNA, POLE/POLD1, RET
Received: 22 Nov 2024; Accepted: 27 Mar 2025.
Copyright: © 2025 Zhang, Zhu, liu, Miao, Mao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ji Miao, Nanjing Drum Tower Hospital, Nanjing, 210008, Jiangsu Province, China
Yonghuan Mao, Nanjing Drum Tower Hospital, Nanjing, 210008, Jiangsu Province, China
Qiang Li, Nanjing Drum Tower Hospital, Nanjing, 210008, Jiangsu Province, China
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