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REVIEW article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1531928
Lipid Metabolism in Multiple Myeloma: Pathogenesis, Therapeutic Opportunities, and Future Directions
Provisionally accepted- Shanghai Changzheng Hospital, Huangpu, Shanghai Municipality, China
Background: Multiple myeloma (MM) is a complex hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. Emerging studies have emphasized the importance of lipid metabolism, which is closely associated with the survival, proliferation, and drug resistance of tumor cells. The hypoxic environment in the bone marrow (BM) contributes to metabolic reprogramming in MM cells, including alterations in metabolite levels, changes in metabolic enzyme activity, and metabolic shifts. Cancer cells possess the ability to adapt their metabolism in order to fulfill their continuously increasing energy demands.In this review, we will discuss the alterations in lipid metabolism during the development of MM, and their reciprocal interactions with the tumor microenvironment.
Keywords: Multiple Myeloma, Lipid Metabolism, therapeutic targets, tumor, Hematology
Received: 21 Nov 2024; Accepted: 11 Feb 2025.
Copyright: © 2025 Wang, Zhang, REN, Chen, Ren, Wu and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiafeng Zhang, Shanghai Changzheng Hospital, Huangpu, Shanghai Municipality, China
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