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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1530924
Ubiquitin specific protease 7 is a potential therapeutic target for gastric cancer
Provisionally accepted- 1 People's Hospital of Zhengzhou University, Zhengzhou, China
- 2 Henan Provincial People's Hospital, Zhengzhou, Henan Province, China
- 3 Jiangsu HengRui Pharmaceuticals, Lianyungang, Jiangsu Province, China
As a deubiquitinase, ubiquitin-specific protease 7 (USP7) plays a vital role in diverse cancers, nevertheless, its role in gastric cancer (GC), which is the fifth leading cause of death in diverse cancers worldwide, has rarely been reported. To gain a comprehensive understanding about USP7 in the progression of GC, 287 paired GC tissues were collected and analyzed. We found that USP7 overexpression in GC tissues was correlated with several parameters of clinicopathology and poor disease-free survival rate. Meanwhile, the abrogation of USP7 suppressed GC cell proliferation by stabilizing p53 and promoting cell cycle arrest both in vitro and in vivo. These results indicate that USP7 may serve as a biomarker for predicting the outcomes of patients with GC. Therefore, USP7 could be a promising therapeutic target for GC treatment.
Keywords: USP7, gastric cancer, proliferation, prognosis, p53
Received: 19 Nov 2024; Accepted: 04 Feb 2025.
Copyright: © 2025 Yu, Wang and Kang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ruili Yu, People's Hospital of Zhengzhou University, Zhengzhou, China
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