AUTHOR=Harbeck Nadia , Brufsky Adam , Rose Chloe Grace , Korytowsky Beata , Chen Connie , Tantakoun Krista , Jazexhi Endri , Nguyen Do Hoang Vien , Bartlett Meaghan , Samjoo Imtiaz A. , Pluard Timothy TITLE=Real-world effectiveness of CDK4/6i in first-line treatment of HR+/HER2− advanced/metastatic breast cancer: updated systematic review JOURNAL=Frontiers in Oncology VOLUME=15 YEAR=2025 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1530391 DOI=10.3389/fonc.2025.1530391 ISSN=2234-943X