94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
CASE REPORT article
Front. Oncol.
Sec. Thoracic Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1525885
Advanced Lung Adenocarcinoma Harboring Uncommon EGFR 19 Del and T790M/trans-C797S Mutations after Resistance: A Case Report and Literature Review
Provisionally accepted- The Affiliated Hospital of Qingdao University, Qingdao, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The most common epidermal growth factor receptor (EGFR) mutation in non-small cell lung cancer (NSCLC) is exon 19 deletion (19del), which is sensitive to EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, uncommon EGFR 19del mutations exhibit varied responses to EGFR-TKI treatment. Research and clinical data on these uncommon subtypes are limited. Additionally, resistance to EGFR-TKIs is inevitable. EGFR C797S is a frequent mechanism of resistance to third-generation EGFR-TKIs, usually occurs in cis with T790M and in 5% of patients in trans. Here, we report a patient diagnosed with lung adenocarcinoma harboring EGFR 19Del L747-A755delinsSKD mutation with co-occurring T790M and trans-C797S mutations, who showed a positive response to combination therapy with first-and third-generation TKIs. This case report suggests an effective treatment option for such patients.
Keywords: Lung Adenocarcinoma, Uncommon mutations, epithelial growth factor receptor, T790M mutation, In trans-C797S
Received: 10 Nov 2024; Accepted: 28 Mar 2025.
Copyright: © 2025 Xiao, Ren, Huanhuan, Zhou, Shao, Han, Na and WANG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: HONGMEI WANG, The Affiliated Hospital of Qingdao University, Qingdao, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.