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REVIEW article
Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 15 - 2025 |
doi: 10.3389/fonc.2025.1525779
CircRNAs in Colorectal Cancer: Potential Roles, Clinical Applications, and Natural Product-Based Regulation
Provisionally accepted
Jingjing Yang 1* Qiqi Fan 1* Yiyun Wang 2* Yuanyue Liu 3* Xiaoning Xu 4* Yeqi Liang 4* Jiakang Xie 4* Jiajie Li 4* Fengting Ai 4* Yong Cao 4* Shangzhen Yu 1*
Jinman Liu 1*- 1 Jiangmen Wuyi Tranditional Chinese Medicine Hospital, Jiangmen, China
- 2 Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
- 3 Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
- 4 Jinan University, Guangzhou, Guangdong Province, China
Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. In recent years, circular RNAs (circRNAs), a novel class of non-coding RNA molecules, have emerged as a research focus due to their unique stability and functional roles. CircRNAs regulate tumor-related signaling pathways through interactions with microRNAs (miRNAs) and proteins, playing key roles in tumorigenesis, progression, invasion, metastasis, and chemoresistance. This review summarizes the role of circRNAs in CRC, particularly their mechanisms in cell proliferation, migration, apoptosis, tumor microenvironment (TME) remodeling, and immune evasion. Aberrant expression of circRNAs holds great potential as diagnostic and prognostic biomarkers as well as therapeutic targets for CRC. Additionally, natural products such as flavonoids and glycosides, by modulating circRNA-miRNA-mRNA networks, offer promising therapeutic strategies. The article also discusses the current technical challenges in circRNA research and its future
Keywords: colorectal cancer (CRC), circular RNAs (circRNAs), biological function, Prognostic biomarkers, potential therapeutic biomarkers, Natural Product-Based Regulation
Received: 13 Nov 2024; Accepted: 10 Jan 2025.
Copyright: © 2025 Yang, Fan, Wang, Liu, Xu, Liang, Xie, Li, Ai, Cao, Yu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jingjing Yang, Jiangmen Wuyi Tranditional Chinese Medicine Hospital, Jiangmen, China
Qiqi Fan, Jiangmen Wuyi Tranditional Chinese Medicine Hospital, Jiangmen, China
Yiyun Wang, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong Province, China
Yuanyue Liu, Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210017, Liaoning Province, China
Xiaoning Xu, Jinan University, Guangzhou, 510632, Guangdong Province, China
Yeqi Liang, Jinan University, Guangzhou, 510632, Guangdong Province, China
Jiakang Xie, Jinan University, Guangzhou, 510632, Guangdong Province, China
Jiajie Li, Jinan University, Guangzhou, 510632, Guangdong Province, China
Fengting Ai, Jinan University, Guangzhou, 510632, Guangdong Province, China
Yong Cao, Jinan University, Guangzhou, 510632, Guangdong Province, China
Shangzhen Yu, Jiangmen Wuyi Tranditional Chinese Medicine Hospital, Jiangmen, China
Jinman Liu, Jiangmen Wuyi Tranditional Chinese Medicine Hospital, Jiangmen, China
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