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REVIEW article

Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1520808

AR and YAP Crosstalk: Impacts on Therapeutic Strategies in Prostate Cancer

Provisionally accepted
Guansong Zheng Guansong Zheng 1Zhaojie Yan Zhaojie Yan 1Junrong Zou Junrong Zou 2,3Xiaofeng Zou Xiaofeng Zou 2*Keqiang Chai Keqiang Chai 4*Guoxi Zhang Guoxi Zhang 2*
  • 1 First Clinical College, Gannan Medical University, 赣州市, China
  • 2 Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
  • 3 Institute of Urology, Gannan Medical University, 赣州市, China
  • 4 Department of Urology, Baiyin First People's Hospital, Baiyin, China

The final, formatted version of the article will be published soon.

    Prostate cancer ranks as one of the most common types of cancer affecting men worldwide, and its progression is shaped by a diverse array of influencing factors. The AR signaling pathway plays a pivotal role in the pathogenesis of prostate cancer. While existing anti-androgen treatments show initial efficacy, they ultimately do not succeed in halting the advancement to CRPC. Recent studies have identified alterations in the Hippo-YAP signaling pathway within prostate cancer, highlighting intricate crosstalk with the AR signaling pathway. In this review, we examine the interactions and underlying mechanisms between AR and YAP, the key molecules in these two signaling pathways. AR regulates the stability and function of YAP by modulating its transcription, translation, and phosphorylation status, while YAP exerts both promotional and inhibitory regulatory effects on AR. Based on these findings, this paper investigates their significant roles in the onset, progression, and therapeutic resistance of prostate cancer, and discusses the clinical potential of YAP in prostate cancer treatment.

    Keywords: prostate cancer, androgen receptor, yes-associated protein, crosstalk, Mechanism

    Received: 31 Oct 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 Zheng, Yan, Zou, Zou, Chai and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiaofeng Zou, Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
    Keqiang Chai, Department of Urology, Baiyin First People's Hospital, Baiyin, China
    Guoxi Zhang, Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.