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CASE REPORT article

Front. Oncol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1519676
This article is part of the Research Topic Novel Therapeutics for Urological Cancers View all articles

Bladder-Sparing Therapy for a Patient with Huge Muscle-Invasive Bladder IMT using 1470 nm Diode Laser En Bloc Resection Followed by Laparoscopic Partial Cystectomy

Provisionally accepted
Junhao Chu Junhao Chu 1Huisheng Yuan Huisheng Yuan 1Zhihui Zhang Zhihui Zhang 1Jiajun Kan Jiajun Kan 1Shishuai Duan Shishuai Duan 1Zilong Wang Zilong Wang 2,3,4*Muwen Wang Muwen Wang 1*
  • 1 Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
  • 2 Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong Province, China
  • 3 Department of Urology, Shandong Provincial Hospital, Jinan, Shandong Province, China
  • 4 Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China

The final, formatted version of the article will be published soon.

    Background: Bladder inflammatory myofibroblastic tumor (IMT) is a rare intermediate malignancy.Muscle-invasive bladder IMT is associated with a high risk of recurrence and metastasis, and bladder-sparing treatments for this condition are still under exploration. This case aims to evaluate the therapeutic efficacy of 1470 nm diode laser transurethral en bloc resection (ERBT) followed by laparoscopic partial cystectomy in the treatment of muscle-invasive bladder IMT.A 23-year-old male patient presented with painless terminal gross hematuria and was treated at Shandong Provincial Hospital of Shandong First Medical University. Computed tomography urography (CTU) and magnetic resonance imaging (MRI) identified a large tumor on the anterior bladder wall with muscle layer invasion, measuring approximately 5.0 × 3.9 × 4.3 cm. The patient underwent 1470 nm laser ERBT, followed by laparoscopic partial cystectomy 35 days later. Pathological examination following 1470 nm laser resection confirmed the diagnosis of an IMT with malignant potential, showing anaplastic lymphoma kinase (ALK) positivity, a Ki-67 index of 20% in hotspot regions, and ALK gene rearrangement detected by fluorescence in situ hybridization (FISH).Pathology after the secondary laparoscopic partial cystectomy showed tumor invasion into the superficial muscle layer, with negative margins at the resection site. MRI and cystoscopy showed no recurrence during 1 year follow-up.This case presents a patient with a huge muscle-invasive bladder IMT who received bladder-sparing therapy through 1470 nm diode laser ERBT followed by laparoscopic partial cystectomy. During subsequent follow-ups, the patient showed good recovery with no signs of recurrence, providing a promising treatment concept for bladder-sparing therapy in muscle-invasive bladder IMT.

    Keywords: inflammatory myofibroblastic tumor, Muscle invasion, Transurethral En Bloc Resection of Bladder Tumor, Laparoscopic partial cystectomy, Bladder tumor, 1470 nm laser, case report

    Received: 30 Oct 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 Chu, Yuan, Zhang, Kan, Duan, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zilong Wang, Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518100, Guangdong Province, China
    Muwen Wang, Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

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