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REVIEW article
Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1519592
This article is part of the Research TopicMelanoma Therapeutics at the CrossroadsView all articles
Rewiring Lipid Metabolism to Enhance Immunotherapy Efficacy in Melanoma: A Frontier in Cancer Treatment
Provisionally accepted
Jian Cheng1*
Lihua Xiong2- 1School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
- 2Chengdu Xinjin District Hospital of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
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Immunotherapy has transformed the landscape of melanoma treatment, offering significant extensions in survival for many patients. Despite these advancements, nearly 50% of melanoma cases remain resistant to such therapies, highlighting the need for novel approaches. Emerging research has identified lipid metabolism reprogramming as a key factor in promoting melanoma progression and resistance to immunotherapy. This reprogramming not only supports tumor growth and metastasis but also creates an immunosuppressive environment that impairs the effectiveness of treatments such as immune checkpoint inhibitors (ICIs). This review delves into the intricate relationship between lipid metabolism and immune system interactions in melanoma. We will explore how alterations in lipid metabolic pathways contribute to immune evasion and therapy resistance, emphasizing recent discoveries in this area. Additionally, we also highlights novel therapeutic strategies targeting lipid metabolism to enhance immune checkpoint inhibitor (ICI) efficacy.
Keywords: Melanoma, Lipid Metabolism, Immunotherapy, Immne checkpoint inhibitor, Fatty acid oxidation (FAO)
Received: 30 Oct 2024; Accepted: 31 Mar 2025.
Copyright: © 2025 Cheng and Xiong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jian Cheng, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.