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CASE REPORT article

Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1519441

Cerebellar metastasis from colorectal cancer: A case report

Provisionally accepted
Carla Ernestina Angulo Rojo Carla Ernestina Angulo Rojo Karen Gaxiola Gastélum Karen Gaxiola Gastélum Luis José Castillo Gaxiola Luis José Castillo Gaxiola ALMA MARLENE GUADRON LLANOS ALMA MARLENE GUADRON LLANOS Javier Abednego Magaña Gómez Javier Abednego Magaña Gómez Diana Laura Baldenebro Félix Diana Laura Baldenebro Félix *
  • Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, Mexico

The final, formatted version of the article will be published soon.

    Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with adenocarcinoma as the most common subtype. While metastasis typically occurs in the liver, lungs, and peritoneal cavity, metastasis to the brain, particularly the cerebellum, is exceedingly rare. Case presentation: This report discusses the case of a 50-year-old woman diagnosed with mucinous adenocarcinoma of the descending colon. Over six years, the patient experienced multiple common metastatic sites, including the liver and lungs, before developing a rare cerebellar metastasis. Despite extensive treatment, including surgery and chemotherapy, the disease progressed, ultimately leading to the patient's demise. This case represents the first documented cerebellar metastasis from CRC in Mexico. Conclusion. This case highlights the altered metastatic patterns in CRC due to advanced therapies that extend survival. Clinicians should remain vigilant for metastasis to uncommon sites, such as the cerebellum, especially in patients with prolonged survival. Further research is needed to understand the mechanisms underlying such metastatic behavior and optimize treatment strategies.

    Keywords: case report, colorectal cancer, Colonic adenocarcinoma, cerebellar metastasis, tumor markers

    Received: 29 Oct 2024; Accepted: 07 Jan 2025.

    Copyright: © 2025 Angulo Rojo, Gaxiola Gastélum, Castillo Gaxiola, GUADRON LLANOS, Magaña Gómez and Baldenebro Félix. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Diana Laura Baldenebro Félix, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, Mexico

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