Correlation analysis on Epidermal Growth Factor Receptor (EGFR) mutations and clinicopathological characteristics in lung adenocarcinomas

Haitao Wang Changhua Ji Hui Li ^* Chengjun Zhou ^*

• Department of Pathology, The Second Hospital of Shandong University, Jinan, Shandong Province, China

To analysis the correlation between EGFR mutations and clinicopathological features in lung adenocarcinomas. 139 lung adenocarcinoma cases from the Second Hospital of Shandong University were conducted molecular detection of EGFR mutations. Multiple clinicopathological characteristics were collected and analyzed to identify the relationship with EGFR mutations. The amplification refractory mutation system (ARMS) was performed to detect the EGFR mutations. During the 139 cases, 96 lung adenocarcinoma cases had EGFR mutations. EGFR mutations were associated with smoking history (P=0.0311), tumor size (P=0.0247), tumor subtype (P=0.0003), rhabdomyoid differentiation (P=0.0237) and extracellular mucus (P=0.0013). Smoking history, tumor size, tumor subtype, rhabdomyoid differentiation and extracellular mucus were related to EGFR mutations in lung adenocarcinoma. These histological characteristics might be meaningful to predict EGFR mutations.