The final, formatted version of the article will be published soon.
CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 |
doi: 10.3389/fonc.2025.1514460
Primary solid pseudopapillary neoplasm of the ovary with "cholesteromalike" denaturation
Provisionally accepted- Zhongshan Hospital, Xiamen University, Xiamen, China
Solid pseudopapillary neoplasms (SPNs) primarily arise in the pancreas and are uncommon in the ovaries. Here, we present a case of ovarian-origin SPN. Alongside the typical solid and pseudopapillary structures, "cholesteroma-like" denaturation areas and tissue degeneration regions are also observed. Immunohistochemistry analysis demonstrates positive results for β-catenin (nucleus), CD99 (dot-like), CD56, and vimentin. Imaging studies rule out pancreatic or other origins. This study aims to enhance comprehension, diagnosis, and differential diagnosis of primary ovarian SPN among pathologists and clinicians, as well as to investigate the origin and management of primary solid pseudopapillary tumors in the ovary.
Keywords: Solid pseudopapillary neoplasm, Ovary, β-catenin, Primarily, cholesteroma-like denaturation
Received: 20 Oct 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 Zhao, lin, liu, bai and liao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ziqing Zhao, Zhongshan Hospital, Xiamen University, Xiamen, China
jiahui lin, Zhongshan Hospital, Xiamen University, Xiamen, China
zhengjin liu, Zhongshan Hospital, Xiamen University, Xiamen, China
tingting bai, Zhongshan Hospital, Xiamen University, Xiamen, China
hongfeng liao, Zhongshan Hospital, Xiamen University, Xiamen, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.