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CASE REPORT article

Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1513254

Exploration of Treatment Strategies for Cerebral Cavernous Malformations: Two Case Reports on Non-Resection Treatment and Literature Review

Provisionally accepted
HAN YIBO HAN YIBO 1,2LIANG DONG LIANG DONG 2,3Jing Guo Jing Guo 4Yibao Wang Yibao Wang 2Yong Wang Yong Wang 2*
  • 1 Department of Organ and Tissue Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
  • 2 Department of Neurosurgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
  • 3 Department of Optical Neuroanatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
  • 4 Shenyang Renren Kangye Hospital, Shenyang, China

The final, formatted version of the article will be published soon.

    Background: Cavernous malformations are common vascular abnormalities of the central nervous system, but cavernous malformations of the cerebral aqueduct are rare. The choice of treatment is influenced by various factors.We report two cases of midbrain cavernous malformations.Both cases involved midbrain lesions obstructing the cerebral aqueduct, leading to obstructive hydrocephalus. The primary symptoms and complaints of the patients were related to hydrocephalus. Prior to surgery, patients underwent comprehensive imaging evaluations and received endoscopic third ventriculostomy rather than tumor resection. Both patients had favorable recoveries. We also reviewed the literature and discussed the choice of treatment strategies.Cavernous malformations are slow-progressing central nervous system lesions with a relatively benign natural course. When selecting a treatment strategy, clinicians should carefully consider the underlying cause of the patient's primary symptoms and the specific objectives of the surgery. Avoiding overly aggressive resection that fails to address the main symptoms and potentially causes irreversible damage is crucial.

    Keywords: Cavernous malformations, midbrain, Hydrocephalus, endoscopic third ventriculostomy, case report

    Received: 18 Oct 2024; Accepted: 10 Jan 2025.

    Copyright: © 2025 YIBO, DONG, Guo, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yong Wang, Department of Neurosurgery, The First Affiliated Hospital of China Medical University, Shenyang, 110000, Liaoning Province, China

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