CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1512036
Synchronous papillary renal neoplasm with reverse polarity and membranous nephropathy：a rare case report
Provisionally accepted
- 1Central Hospital Affiliated to Shandong First Medical University, Jinan, China
- 2Shandong Provincial Hospital, Jinan, Shandong Province, China
- 3Second People's Hospital of Liaocheng, Liaocheng, Shandong Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background:Papillary renal neoplasm with reverse polarity (PRNRP) is a relatively rare subtype of papillary renal cell carcinoma (PRCC) and is considered to be a tumor of low malignant potential. Membranous nephropathy (MN) is frequently associated with malignant tumors but rarely accompanies renal cell carcinoma.Synchronous papillary renal neoplasm with reverse polarity and membranous nephropathy has not been reported in the current study.( We searched in PubMed, Web of Science databases, Embase, and Medline in the English language from 1970 to October 2024. The keywords used were "papillary renal neoplasm with reverse polarity " and " membranous nephropathy".)Case presentation: A 66-year-old man was admitted to the hospital with lower extremity edema and hypertension and presented with nephrotic syndrome including hypoalbuminemia and proteinuria. Enhanced CT scan showed a 3.7*3.0 cm round-like soft tissue density foci at the lower pole of the left kidney, with obvious inhomogeneous enhancement. The patient underwent a laparoscopic partial nephrectomy of the left kidney.Histologic and immunohistochemical results showed typical features of PRNRP, including a papillary structure covered by a single layer of cuboidal cells with finely grained eosinophilic cytoplasm, nuclei that were mostly regular and apically located, and GATA3 (+). The biopsy of pericarcinoma tissue showed membranous nephropathy and glomerular segmental sclerosis. The patient's nephrotic syndrome resolved and the tumor did not recur or metastasize during 22 months of postoperative follow-up.We reported a case of synchronous papillary renal neoplasm with reverse polarity with membranous nephropathy. The mechanism of renal tumor-associated nephrotic syndrome is unclear and more medical records are needed for research.
Keywords: Papillary renal cell carcinoma, Reverse polarity, Membranous nephropathy, Nephrotic Syndrome, case report
Received: 16 Oct 2024; Accepted: 21 Apr 2025.
Copyright: © 2025 xing, zhong, li, cao, he and liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
li he, Shandong Provincial Hospital, Jinan, 250021, Shandong Province, China
teng xiao liu, Second People's Hospital of Liaocheng, Liaocheng, 252600, Shandong Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.