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CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1510930
SMARCA4-deficient Undifferentiated Carcinoma Co-existing with Primary Endometrial Gastric (or Gastrointestinal) -Type Carcinoma：A Case Report
Provisionally accepted
Fan Yang 1
Haixiao Fu 1
Xiang Zheng 1* Yuzhong Yang 1* Quyan Zhou 2* Yuanna Liang 1* Jinghua Zheng 1* Jing Lin 1*- 1 Affiliated Hospital of Guilin Medical University, Guilin, China
- 2 Guanyang County People's Hospital, Guilin, China
Dedifferentiated endometrial carcinoma (DEC) is a rare and highly malignant endometrial tumor consisting of both undifferentiated endometrial carcinoma (UEC) and differentiated components (that are typically grade 1 or 2 endometrioid carcinomas). By contrast, the coexistence of UEC with a high-grade endometrial carcinoma has not been well reported. Primary endometrial gastric (gastrointestinal)-type carcinoma (PEGT-carcinoma) is a newly classified and rare type of female genital tract cancer, this neoplasm belongs to high-grade endometrial carcinoma and tends to have a poor outcome. In this study, we reported an atypical case of DEC composed of SMARCA4-deficient UEC and PEGT-carcinoma and reviewed its clinicopathological features.
Keywords: endometrial carcinoma, UEC, dec, PEGT-carcinoma, SMARCA4-deficient
Received: 14 Oct 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 Yang, Fu, Zheng, Yang, Zhou, Liang, Zheng and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiang Zheng, Affiliated Hospital of Guilin Medical University, Guilin, China
Yuzhong Yang, Affiliated Hospital of Guilin Medical University, Guilin, China
Quyan Zhou, Guanyang County People's Hospital, Guilin, China
Yuanna Liang, Affiliated Hospital of Guilin Medical University, Guilin, China
Jinghua Zheng, Affiliated Hospital of Guilin Medical University, Guilin, China
Jing Lin, Affiliated Hospital of Guilin Medical University, Guilin, China
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